Table 1.
Disc1 svΔ2 contributes to significant changes in neural microstructure in salient regions implicated in psychiatric illness
| DTI measure | Hemi. | ROI | Mean (±SEM) | p-value | Mean (±SEM) | p-value | ||
|---|---|---|---|---|---|---|---|---|
| Control male | Disc1 ΔN68/ΔN68 male | Male | Control female | Disc1 ΔN68/ΔN68 female | Female | |||
| FA | Right | HC | .31328 (±.00027) | .31374 (±.00055) | .772 | .31154 (±.00040) | .31217 (±.00038) | .652 |
| EC | .45444 (±.00032) | .45761 (±.00068) | .131 | .45583 (±.00101) | .45581 (±.00077) | .993 | ||
| BG | .29129 (±.00036) | .29081 (±.00037) | .716 | .29213 (±.00045) | .29202 (±.00040) | .945 | ||
| IC | .44397 (±.00044) | .44442 (±.00150) | .912 | .44048 (±.00241) | .44777 (±.00104) | .296 | ||
| NC | .28768 (±.00010) | .28563 (±.00015) | .001* | .28781 (±.00029) | .28816 (±.00019) | .696 | ||
| CC | .52396 (±.00024) | .52346 (±.00056) | .749 | .51810 (±.00059) | .52261 (±.00028) | .024 | ||
| Left | HC | .32838 (±.00024) | .32878 (±.00048) | .772 | .33096 (±.00085) | .32766 (±.00025) | .178 | |
| EC | .42046 (±.00048) | .41847 (±.00112) | .532 | .41288 (±.00164) | .41917 (±.00093) | .209 | ||
| BG | .30576 (±.00031) | .30126 (±.00049) | .013 | .30399 (±.00042) | .30368 (±.00038) | .831 | ||
| IC | .55447 (±.00059) | .56802 (±.00182) | . 027 | .57168 (±.00118) | .56001 (±.00164) | .043 | ||
| NC | .28813 (±.00034) | .28689 (±.00037) | .076 | .28946 (±.00013) | .28743 (±.00028) | .033 | ||
| CC | .57720 (±.00060) | .57595 (±.00051) | .346 | .57198 (±.00072) | .57341 (±.00105) | .658 | ||
| NDI | Right | HC | .28941 (±.00340) | .23560 (±.00206) | < .001* | .23103 (±.00517) | .30632 (±.00796) | .011 |
| EC | .30236 (±.00541) | .23182 (±.00201) | .001* | .27036 (±.01174) | .29071 (±.00652) | .554 | ||
| BG | .28386 (±.00481) | .22498 (±.00248) | .003* | .22495 (±.00523) | .29500 (±.01196) | .065 | ||
| IC | .38430 (±.00245) | .30675 (±.00613) | .002* | .29660 (±.00560) | .35418 (±.00714) | .028 | ||
| NC | .33364 (±.00438) | .30249 (±.00395) | .052 | .31497 (±.00439) | .34905 (±.00744) | .145 | ||
| CC | .41147 (±.00386) | .31803 (±.00591) | < .001* | .27198 (±.00352) | .38752 (±.00487) | < .001* | ||
| Left | HC | .28968 (±.00207) | .23452 (±.00275) | < .001* | .24458 (±.00589) | .29333 (±.00656) | .048 | |
| EC | .29344 (±.00187) | .24496 (±.00186) | < . 001* | .24774 (±.00552) | .29113 (±.00720) | .082 | ||
| BG | .28773 (±.00294) | .23324 (±.00257) | < .001 | .23410 (±.00451) | .30759 (±.01068) | .037 | ||
| IC | .44053 (±.00370) | .33749 (±.00524) | < .001* | .33155 (±.00351) | .36690 (±.01050) | .239 | ||
| NC | .35425 (±.00287) | .32002 (±.00379) | .015 | .31738 (±.00462) | .35627 (±.00471) | .037 | ||
| CC | .43527 (±.00341) | .34018 (±.00519) | < .001* | .30457 (±.00596) | .38664 (±.00506) | .002 | ||
| ODI | Right | HC | .20010 (±.00465) | .17447 (±.00389) | .128 | .18642 (±.00829) | .24960 (±.01015) | .079 |
| EC | .18074 (±.00363) | .15364 (±.00418) | .080 | .19363 (±.01058) | .19580 (±.00838) | .949 | ||
| BG | .25877 (±.00590) | .19671 (±.00366) | .007* | .20442 (±.00696) | .27633 (±.01724) | .161 | ||
| IC | .17413 (±.00344) | .15744 (±.00956) | .530 | .19334 (±.01802) | .21625 (±.01752) | .718 | ||
| NC | .23216 (±.00488) | .20261 (±.00412) | .100 | .20200 (±.00440) | .27158 (±.00677) | .007 | ||
| CC | .12962 (±.00245) | .14678 (±.01170) | .582 | .19095 (±.01923) | .13683 (±.00527) | .312 | ||
| Left | HC | .19648 (±.00173) | .16911 (±.00252) | .005* | .20201 (±.00865) | .22323 (±.00762) | .470 | |
| EC | .18265 (±.00260) | .16419 (±.00563) | .268 | .18702 (±.01109) | .19980 (±.01016) | .736 | ||
| BG | .24587 (±.00485) | .20683 (±.00245) | .024 | .22083 (±.00696) | .28836 (±.01386) | .117 | ||
| IC | .13344 (±.00378) | .15946 (±.01595) | .544 | .24072 (±.02132) | .27034 (±.01301) | .641 | ||
| NC | .24230 (±.00207) | .22947 (±.00500) | .371 | .25140 (±.00408) | .25701 (±.00814) | .809 | ||
| CC | .12929 (±.00209) | .14124 (±.01569) | .770 | .20886 (±.02381) | .13412 (±.00450) | .260 | ||
All values are mean ± s.e.m. Units of measure for FA, NDI, and ODI are [10−3 mm2/s]. Bolded and italicized p-values are statistically significant. Starred p-values are statistically significant after controlling the false discovery rate with the Benjamini-Hochberg procedure (false discovery rate = .05). Regions of interest (ROIs) correspond to ROIs derived from the P72 UNC Atlas
For control male samples, n = 7. For all other sample groups, n = 6
Hemi. hemisphere, FA fractional anisotropy, NDI neurite density index, ODI orientation dispersion index, HC hippocampus, EC external capsule, BG basal ganglia, IC internal capsule, NC neocortex, CC corpus callosum