Table 4.

Summary of studies of NIRS in monitoring cerebral blood oxygenation.

Study	# of patients	Patients character	Etiology	Target area	Measurement	Method	Clinical applications
Nemoto et al. (62)	2	85-yr-old female; 62-yr-old female	Infarction in the territory of MCA	Frontal-temporal or frontal-parietal cortices	Oxygen saturation	NIRS oximetry	Monitor CBO changes
Damian et al. (63)	24	15 male, 9 female; 43-77	Complete MCA stroke and brain swelling	Bilateral frontal lobe	Oxygen saturation	NIRS oximetry	Monitor CBO changes
Sakatani et al. (64)	/	/	/	/	Oxygen saturation	NIRS oximetry	Clarify CBO changes occurring in stroke and brain tumors
Aries et al. (65)	9	3 male, 6 female; age 71 ± 10	Acute stroke	Bilateral forehead	Oxygen saturation	NIRS oximetry	Monitor CBO changes
Mundiyanapurath et al. (66)	44	59–82	Acute ischemic stroke		Oxygen saturation	NIRS oximetry	Compare therapeutic effect
Liebig et al. (67)	/	/	/	/	Cerebral oxygenation	NIRS oximetry	Compare therapeutic effect
Hametner et al. (68)	43	22 male, 21 female; 65–79	Acute ischemic stroke	Forehead	Cerebral oxygenation	NIRS oximetry	Measure rSO2
Hashimoto et al. (69)	1	77-year-old man	CI	Bilateral frontal lobe	Regional cerebral oxygen saturation (rSO2)	NIRS oximetry	Monitor CBO changes
Ritzenthaler et al. (70)	3	56-year-old man; 52-year-old man; 40-year-old pregnant woman	MCA occlusion	Bilateral forehead	Regional cerebral oxygen saturation (rSO3)	NIRS oximetry	Assess rSO2 changes
Nakamura et al. (71)	5	Four male, one female, 65.6 ± 10.6 years	Stroke	Injured area	Δ[Oxy-Hb] and Δ[Deoxy-Hb].	NIRS	Evaluate effect of revascularization on the abnormal evoked CBO responses
Vernieri et al. (72)	2	58-year-old man; 61-year-old man	Ischemic stroke	MCA	Cerebral oxygenation	NIRS oximetry	Evaluate the effects of hypercapnia
Moreau et al. (73)	5	2 male,3 female; median age 64 years old	Acute stroke	MCA	Cerebral oxygenation	NIRS oximetry	Investigate brain oxygenation in the first few hours of stroke onset

CBO, cerebral blood oxygenation.