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. 2019 Jan 31;10:100. doi: 10.3389/fimmu.2019.00100

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Copyright © 2019 Mariotti, Servaas, Rossato, Tamassia, Cassatella, Cossu, Beretta, van der Kroef, Radstake and Bazzoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LPS modulates the expression of long noncoding transcripts in human monocytes. CD14+ monocytes were cultured for 1.5 or 4 h with LPS (100 ng/ml) or left untreated (t0). Two pools of three donors for each condition were used to create polyA library for RNA-seq. Sequencing data were analyzed as described in Materials and Methods. The expression levels of the LPS-modulated (adjusted p < 0.05) lncRNAs (A) are shown as row mean-centered z-Score of the variance stabilized data (vsd). (B) The percentage of up- and down-regulated lncRNAs modulated by LPS. (C) The percentage of early, early & transient and late lncRNAs modulated by LPS. K-means clustering analysis was applied on the significantly modulated lncRNAs. Early modulated (D), early and transiently modulated (E) as well as late modulated (F) lncRNAs are shown. The expression of each lncRNA belonging to the three groups is shown. LncRNAs up regulated and down regulated by LPS are shown separately. NRIR expression is highlighted in red. LncRNA expression is depicted as row mean-centered z-Score of the variance stabilized data (vsd), number of lncRNA belonging to each KMC group is shown.