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. 2019 Jan 31;10:100. doi: 10.3389/fimmu.2019.00100

Figure 3.

Figure 3

NRIR expression is increased in monocytes from SSc patients and correlates with the IFN-score. RNA sequencing data of CD14+ monocytes from SSc patients and matched healthy controls (HC) from both the definite SSc and non-fibrotic SSc cohorts were analyzed as described in Meterials and Methods. NRIR, PSMB8-AS1, RP5-1091N2.9, and RP11-24F11.2 expression were considered. LncRNAs expression in HC and patients with established Systemic Sclerosis (ncSSc, lcSSc, and dcSSc, definite-SSc cohort) (A) and in patients with early stages of SSc (eaSSc and ncSSc, non-fibrotic SSc cohort) (B) is shown. *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant, by Wald test (C) Correlation of NRIR expression with the IFN-score of HC (gray), ncSSc (red), lcSSc (green), and dcSSc (blue) patients is depicted. (D) Correlation of NRIR expression with the IFN-score of HC (gray), eaSSc (black) and ncSSc (red) patients is shown. Spearman's Rho and p-value are reported. NRIR expression levels are expressed as vsd, IFN Score was calculated according to Brkic et al. (16).