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. 2019 Jan 31;10:100. doi: 10.3389/fimmu.2019.00100

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Copyright © 2019 Mariotti, Servaas, Rossato, Tamassia, Cassatella, Cossu, Beretta, van der Kroef, Radstake and Bazzoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NRIR regulated proteins CXCL10 and CXCL11 are elevated in plasma of SSc patients. CD14+ monocytes from seven different donors were transfected with si-NRIR or si-CTR and 18 h later were stimulated with LPS for 8 h. Cell-free supernatants were collected, and the release of CXCL10 (A) and CCL8 (B) was measured by the multiplex immunoassay. ^*p < 0.05 by Wilcoxon matched-pairs signed rank test. CXCL10 (C) and CXCL11 (D) level in plasma from SSc patients and matched HC was measured by the multiplex immunoassay. eaSSc, early SSc; ncSSc, non-cutaneous SSc; lcSSc, limited-cutaneous SSc; dcSSc, diffuse-cutaneous SSc. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 by Mann Whitney test.