Table 1.
Top Ten Serum Ions That Were Significantly Altered in Mice Treated With MCD Diet for 8 Weeks Compared With Mice Treated With MCS Diet*
| Rank | RT (min) | Found (m/z) | Identity | Mass Error (ppm) | Elemental Composition |
|---|---|---|---|---|---|
| Increased ions | |||||
| 1 | 2.55 | 514.2843 | Tauro-β-muricholate | 0.97 | C26H45NO7S |
| 2 | 4.71 | 319.2271 | 12-Hydroxyeicosatetraenoic acid | 0.63 | C20H32O3 |
| 3 | 2.92 | 514.2829 | Taurocholate | 1.75 | C26H45NO7S |
| 4 | 6.44 | 381.1723 | Not determined | ||
| 5 | 5.81 | 327.2319 | Docosahexaenoic acid | 1.53 | C22H32O2 |
| 6 | 5.97 | 379.1568 | Not determined | ||
| 7 | 5.97 | 279.2318 | Linoleic acid | 2.15 | C18H32O2 |
| 8 | 6.44 | 281.2474 | Oleic acid | 2.49 | C18H34O2 |
| 9 | 2.59 | 512.2684 | Not determined | ||
| 10 | 4.34 | 241.1808 | Not determined | ||
| Decreased ions | |||||
| 1 | 4.78 | 540.3303 | Palmitoyl-LPC (16:0-LPC) | 0.37 | C25H52NO9P |
| 2 | 5.40 | 568.3615 | Stearoyl-LPC (18:0-LPC) | 0.18 | C27H56NO9P |
| 3 | 4.94 | 566.3463 | Oleoyl-LPC (18:1-LPC) | 0.88 | C27H54NO9P |
| 4 | 4.57 | 564.3303 | Linoleoyl-LPC (18:2-LPC) | 0.35 | C27H52NO9P |
| 5 | 0.28 | 215.0325 | Not determined | ||
| 6 | 4.57 | 588.3306 | Arachidonoyl-LPC (20:4-LPC) | 0.85 | C29H52NO9P |
| 7 | 4.53 | 612.3291 | Docosahexanoyl-LPC (22:6-LPC) | 1.63 | C31H52NO9P |
| 8 | 4.40 | 538.3137 | Palmitoleoyl-LPC (16:1-LPC) | 1.49 | C25H50NO9P |
| 9 | 4.53 | 524.2776 | Not determined | ||
| 10 | 4.77 | 590.3455 | Not determined | ||
*
The ion ranking, based on OPLS analysis, shows the highest confidence and greatest contribution to separation between MCD and MCS diet treatment. RT, retention time; LPC, lysophosphatidylcholine.