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. 2019 Feb 11;2(1):e201800186. doi: 10.26508/lsa.201800186

Figure 4. Vamorolone is an effective MR antagonist in vivo.

Figure 4.

Mice were treated with daily oral drug (vehicle, vamorolone, eplerenone, or spironolactone) and implanted with osmotic pumps that secreted either aldosterone or vehicle for 6 wk. Kidney size was assayed as an epithelial MR target tissue, where aldosterone-specificity of the MR is maintained through expression of the glucocorticoid-inactivating enzyme HSD11B2. (A) Representative kidney images are provided. (B) Aldosterone induced an increase in kidney mass in both wild-type and mdx. This was prevented in mdx by all three MR antagonists. (n ≥ 8 per group; ***P < 0.0005, ANOVA with post hoc test versus mdx + aldosterone in red; ##P < 0.005, t test comparing WT groups; V = Vamorolone, E = Eplerenone, S = Spironolactone).