Table 2.
Top 20-ranked repositioned drug candidates. NCT**: SCZ drugs from clinical trials. PMID**: SCZ drugs from biomedical literature. FDA-approved SCZ drugs are highlighted.
| Rank | Drug | Evidence | Rank | Drug | Evidence |
|---|---|---|---|---|---|
| 1 | quetiapine | FDA-approved | 11 | clozapine | FDA-approved |
| 2 | sertraline | NCT00169988, NCT00531518 | 12 | trazodone | NCT00659919 |
| 3 | risperidone | FDA-approved | 13 | valproic acid |
NCT00194025, NCT01094249, NCT02011750 |
| 4 | alprazolam | PMID3289523, PMID1348161, PMID12516314 |
14 | lithium |
NCT00202306 NCT00183443 NCT00202293 |
| 5 | olanzapine | FDA-approved | 15 | donepezil |
NCT01490567, NCT00465283, NCT00206947 |
| 6 | fluoxetine |
NCT00531518, NCT02022709 |
16 | memantine |
NCT02001103 NCT00757978 NCT00097942 |
| 7 | aripiprazole | FDA-approved | 17 | sulpiride |
NCT00654576, NCT02307396 |
| 8 | citalopram |
NCT00893256, NCT00047450, NCT01032083, NCT01032083 |
18 | bupropion |
NCT01111149, NCT00307203 |
| 9 | haloperidol | FDA-approved | 19 | lorazepam |
NCT00797277, NCT00431184, NCT00159133 |
| 10 | levetiracetam | PMID12609283, PMID19265183 |
20 | ziprasidone | FDA-approved |