Table III.
Biological properties of Pxt-related peptides
| Peptide | MIC |
Hemolytic activity (at 50 µm) | Histamine release (at 10 µm) | |||||
|---|---|---|---|---|---|---|---|---|
| Escherichia coli (µM) | Pseudomonas aeruginosa (µM) | Saphylococcus aureus (µM) | Micrococcus luteus (µM) | Saccharomyces cerevisiae (µM) | Candida albicans (µM) | |||
| Pxt-2 | <12.5 | <50 | <12.5 | <25 | ND | ND | 2.0% | 22.8% |
| Pxt-5 | <50 | <50 | <12.5 | <12.5 | Significant | ND | 69.8% | 32.8% |
| Pxt-12 | <12.5 | <50 | <12.5 | <50 | Significant | ND | 0% | 25.6% |
| Reverse Pxt-2 | <12.5 | <50 | <12.5 | <50 | Significant | ND | 1.5% | 50.4% |
| Reverse Pxt-5 | <12.5 | <50 | <12.5 | <25 | Significant | ND | 5.2% | 46.5% |
| Reverse Pxt-12 | ND | ND | ND | ND | ND | ND | 0% | 25.6% |
| Magainin 1 | <12.5 | <25 | <25 | Significant | <50 | ND | – | – |
| Mastoparan | – | – | – | – | – | – | 13.5% | 31.1% |
| Melittina | – | – | – | – | – | – | 100% | 64.3% |
ND, not detected; –, determined; significant, bacterial growth was suppressed in the presence of peptides.
aHemolytic activity of melittin at 10 µM was indicated.