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. 2019 Feb 12;7:19. doi: 10.1186/s40478-019-0672-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Degeneration of upper motor neurons. a Loss of Betz cells. (Arrows) A few remaining Betz cells. (Arrowheads) Numerous unstained CWPs that tend to be densely distributed in the deep cortical layers. b Degeneration with evident atrophy of the pyramidal tract at the level of the medulla oblongata. c, d Degeneration in the lateral tract in the thoracic (c) and lumbar cords (d). The anterior horn cells are well preserved in number (d). e Remarkable Aβ deposits in the anterior horns in the lumbar cord, while no Aβ deposit is seen in the corticospinal tract. f A high power view of Aβ deposits in the anterior horn in the lumbar cord. Scale bars = a 300 μm, b-e 1 mm, f 50 μm. a-d Klüver-Barrera stain. e, f 12B2 immunohistochemistry