Fig. 8.

Pathological findings in the substantia nigra and limbic system. a Severe loss of pigmented neurons in the substantia nigra. The corticospinal tract is also severely degenerated. Klüver-Barrera stain. b Glial proliferation with free melanin in the substantia nigra. Hematoxylin-eosin stain. c Phosphorylated tau-positive dystrophic neurites and NFTs in the substantia nigra. AT8 immunohistochemistry. d Phosphorylated α-synuclein-positive Lewy neurites in the substantia nigra. Psyn#64 immunohistochemistry. (e, f) Phosphorylated TDP-43-positive neurocytoplasmic inclusions in the hippocampal dentate gyrus (e) and occipitotemporal gyrus (f). pS409/410–2 immunohistochemistry. g An intranuclear inclusion immunopositive for phosphorylated TDP-43. The occipitotemporal gyrus. pS409/410–2 immunohistochemistry. Scale bars = a 1 mm, b, c 50 μm, d-f 40 μm, g 5 μm