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. 2019 Feb 11;50:12. doi: 10.1186/s13567-019-0631-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Antibody response against IBV (A) and NDV (B) in 1-day-old SPF chicks vaccinated at day 1 and day 14 of age with different rNDV vectored IBV vaccine candidates. A The level of IBV-specific antibodies in chicken serum samples on week 5 (prior to challenge) was determined by ELISA. Mean absorbance values and SEM are shown for each group. Statistically significant differences versus the control group are indicated by asterisk. B The level of NDV-specific antibody titers in chicken serum samples on week 2 (prior to boost) and on week 5 (prior to challenge) were determined by hemagglutination inhibition (HI) assay. Mean and SEM of each group are shown.