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. 2019 Feb 11;15:55. doi: 10.1186/s12917-019-1797-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Schematic explanation of a checkerboard experiment in a 96-multiwell-plate. This example shows an enhanced efficacy of two drug combinations. The antibacterial agent is applied along the columns and the antihistamine along the rows, both in increasing concentrations. The decrease of bacterial growth is presented schematically by fading shades of gray. “NG” indicates no growth of bacteria. In this example, the effect of the antibacterial agent is enhanced in well C4 (circled)