Table 3.
Comparison of immunological profiles in the three subtypes of achalasia
| Biomarker | Achalasia Type 1 (n = 13) | Achalasia Type 2 (n = 32) | Achalasia Type 3 (n = 8) | GERD (n = 21) | EoE (n = 22) | P-valuea |
|---|---|---|---|---|---|---|
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | ||
| IL-6 | 2.68 (2.16) | 2.35 (2.40) | 3.65 (2.53) | 2.06 (4.56) | 1.71 (1.02) | 0.04 |
| IL-12p70 | 1.44 (1.24) | 1.43 (0.85) | 1. 72 (1.95) | 1.19 (1.38) | 2.35 (1.48) | 0.31 |
| IL-17 | 6.85 (6.49) | 8.28 (5.36) | 98.93 (3.95) | 5.9 (8.10) | 9.96 (8.05) | 0.25 |
| IL-22 | 12.82 (9.14) | 11.82 (6.14) | 14.52 (5.33) | 11.35 (6.28) | 10.28 (3.53) | 0.14 |
| IL-23 | 13.45 (17.44) | 23.88 (14.10) | 25.64 (17.72) | 16.45 (13.65) | 26.58 (17.86) | 0.18 |
| TNF-α | 4.06 (1.15) | 4.03 (1.56) | 4.16 (2.40) | 4.12 (1.32) | 3.97 (2.12) | 0.9 |
| IFN-γ | 5.63 (1.21) | 5.59 (2.33) | 4.47 (0.94) | 6.02 (2.05) | 3.97 (2.12) | 0.290.16 |
a - Kruskal–Wallis rank sum test to compare overall differences between groups