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. 2019 Feb 11;20:128. doi: 10.1186/s12864-019-5459-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Chromosome 23 had strong selection signatures identified by long-range frequency changes. a. The bovine MHC region had the largest long-range AFD between Groups I and III due to the 40 years of selection. b. The bovine MHC region also had large long-range AFD between Groups I and IIIb (the elite group) due to the 40 years of selection. c. Contemporary Holsteins (Group III) had long-range heterozygosity decreases in the MHC region relative to Holsteins unselected since 1964 (Group I). d. The elite group (Group IIIb) also had long-range heterozygosity decreases in the MHC region but had heterozygosity increases in the 28.8–31.3 Mb region with a large cluster of 297 genes