Table 1.

Accordance of the package sizes of selected drugs with guidelines for sore throat I

Drug	Package size	ISKRAa	Min No. of Packages	Extra units	IDSAb	Min No. of Packages	Extra units	NICEc
Amoxicillin	16x500 mgd	n/a			2x500 mg, 10 days	2	12	n/a
					1x1000 mg, 10 days	2	12
	20x500 mg	n/a			2x500 mg, 10 days	1	0
					1x1000 mg, 10 days	1	0
	16x1000 mgd	n/a			2x500 mg, 10 days	1	6
					1x1000 mg, 10 days	1	6
	20x1000 mge	n/a			2x500 mg, 10 days	n/a	n/a
					1x1000 mg, 10 days	1	10
Co-amoxiclav	10x1000 mg	2x1000 mg, 10 days	2	0	n/a			n/a
	12x1000 mgd	2x1000 mg, 10 days	2	4	n/a
	14x1000 mgd	2x1000 mg, 10 days	2	8	n/a
	16x1000 mg	2x1000 mg, 10 days	2	12	n/a
	20x1000 mg	2x1000 mg, 10 days	1	0	n/a
	21x1000 mg	2x1000 mg, 10 days	1	1	n/a
	24x1000 mg	2x1000 mg, 10 days	1	4	n/a
	30x1000 mg	2x1000 mg, 10 days	1	10	n/a
Azithromycin	6x125 mg	1x500 mg, 3 days	2	0	1x500 mg, 5 days	4	4	n/a
	6x250 mgd	1x500 mg, 3 days	1	0	1x500 mg, 5 days	2	2
	1x500 mg	1x500 mg, 3 days	3	0	1x500 mg, 5 days	5	0
	2x500 mg	1x500 mg, 3 days	2	1	1x500 mg, 5 days	3	1
	3x500 mgd	1x500 mg, 3 days	1	0	1x500 mg, 5 days	2	1
	6x500 mg	1x500 mg, 3 days	1	3	1x500 mg, 5 days	1	1
	12x500 mg	1x500 mg, 3 days	1	9	1x500 mg, 5 days	1	7
	24x500 mg	1x500 mg, 3 days	1	21	1x500 mg, 5 days	1	19
	1x1000 mgd	1x500 mg, 3 days	n/a	n/a	1x500 mg, 5 days	n/a	n/a
	2x1000 mg	1x500 mg, 3 days	n/a	n/a	1x500 mg, 5 days	n/a	n/a
	3x1000 mg	1x500 mg, 3 days	n/a	n/a	1x500 mg, 5 days	n/a	n/a
	6x1000 mg	1x500 mg, 3 days	n/a	n/a	1x500 mg, 5 days	n/a	n/a
Cephalexin	16x500 mgd	n/a			2x500 mg, 10 days	2	12	n/a
	16x1000 mgd	n/a			2x500 mg, 10 days	n/a	n/a
Clindamycin	16x150 mgd	3x300 mg, 10 days	4	4	3x300 mg, 10 days	4	4	n/a
	16x300 mgd	3x300 mg, 10 days	2	2	3x300 mg, 10 days	2	2
	16x600 mgd	3x300 mg, 10 days	1	1	3x300 mg, 10 days	1	1
	32x600 mgd	3x300 mg, 10 days	1	17	3x300 mg, 10 days	1	17

Co-amoxiclav – amoxicillin and clavulanic acid; n/a – not applicable; extra units of drugs are presented with reference to the original formulation

^aThe Intersectoral Society for Antibiotic Resistance Control (ISKRA) guidelines on sore throat: diagnostic and therapeutic approach – Croatian national guidelines

^bClinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America

^cNational Institute for Health and Care Excellence (NICE) Sore throat (acute): antimicrobial prescribing

^dincluded in Croatian national reimbursement lists on 1^st of August 2018

^eincluded in Croatian national reimbursement lists prior to 1^st of August 2018 (from 29^th of November 2012)