Table 2.

Accordance of the package sizes of selected drugs with guidelines for sore throat II

Drug	Package size	ISKRAa	Min No. of Packages	Extra units	IDSAb	Min No. of Packages	Extra units	NICEc	Min No. of Packages	Extra units
Clarithromycin	14x250 mgd	2x250 mg, 10 days	2	8	2x250 mg, 10 days	2	8	2x250-500 mg, 5 days	1	4
	5x500 mg	2x250 mg, 10 days	n/a		2x250 mg, 10 days	n/a		2x250-500 mg, 5 days	2	0
	7x500 mgd	2x250 mg, 10 days	n/a		2x250 mg, 10 days	n/a		2x250-500 mg, 5 days	2	4
	14x500 mgd	2x250 mg, 10 days	n/a		2x250 mg, 10 days	n/a		2x250-500 mg, 5 days	1	4
Penicillin V	30x1000000 IUd	3x1 500 000 IU, 10 days	2	15	4x250 mg, 10 days	n/a		4x500 mg, 5-10 days	n/a
					2x500 mg, 10 days			2x1000 mg, 5-10 days
	30x1500000 IUd	3x1 500 000 IU, 10 days	1	0	4x250 mg, 10 days	n/a		4x500 mg, 5-10 days	n/a
					2x500 mg, 10 days			2x1000 mg, 5-10 days
Erythromycin	16x250 mgd	n/a			n/a			4x250-500 mg, 5 days	3	8
								2x500-1000 mg, 5 days	3	8

n/a – not applicable; IU-international unit; extra units of drugs are presented with reference to the original formulation

^aThe Intersectoral Society for Antibiotic Resistance Control (ISKRA) guidelines on sore throat: diagnostic and therapeutic approach – Croatian national guidelines

^bClinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America

^cNational Institute for Health and Care Excellence (NICE) Sore throat (acute): antimicrobial prescribing

^dincluded in Croatian national reimbursement lists on 1^st of August 2018