Table 3.

Accordance of the package sizes of selected drugs with guidelines for urinary tract infections I

Drug	Package size	ISKRAa	Min No. of packages	Extra units	IDSAb
Co-amoxiclav	10x1000 mg	2x1000 mg, 7 days	2	6	n/a
		2x1000 mg, 10-14 days	2 (10 days)	0
		2x1000 mg, 14 days	3	2
		2x1000 mg, 28 days	6	4
	12x1000mgc	2x1000 mg, 7 days	2	10
		2x1000 mg, 10-14 days	2 (12 days)	0
		2x1000 mg, 14 days	3	8
		2x1000 mg, 28 days	5	4
	14x1000 mgc	2x1000 mg, 7 days	1	0
		2x1000 mg, 10-14 days	2 (14 days)	0
		2x1000 mg, 14 days	2	0
		2x1000 mg, 28 days	4	0
	16x1000 mg	2x1000 mg, 7 days	1	2
		2x1000 mg, 10-14 days	2 (14 days)	4
		2x1000 mg, 14 days	2	4
		2x1000 mg, 28 days	4	8
	20x1000 mg	2x1000 mg, 7 days	1	6
		2x1000 mg, 10-14 days	1 (10 days)	0
		2x1000 mg, 14 days	2	12
		2x1000 mg, 28 days	3	4
	21x1000 mg	2x1000 mg, 7 days	1	7
		2x1000 mg, 10-14 days	1 (10 days)	1
		2x1000 mg, 14 days	2	14
		2x1000 mg, 28 days	3	7
	24x1000 mg	2x1000 mg, 7 days	1	10
		2x1000 mg, 10-14 days	1 (12 days)	0
		2x1000 mg, 14 days	2	20
		2x1000 mg, 28 days	3	16
	30x1000 mg	2x1000 mg, 7 days	1	16
		2x1000 mg, 10-14 days	1 (14 days)	2
		2x1000 mg, 14 days	1	2
		2x1000 mg, 28 days	2	4
Cephalexin	16x500 mgc	2x1000 mg, 7 days	2	4	n/a
	16x1000 mgc	2x1000 mg, 7 days	1	2
Cefixime	5x400 mgc	1x400 mg, 10-14 days	2 (10 days)	0	n/a
		1x400 mg, 14 days	3	1
		1x400 mg, 28 days	6	2
	10x400 mgc	1x400 mg, 10-14 days	1 (10 days)	0
		1x400 mg, 14 days	2	6
		1x400 mg, 28 days	3	2
Cefuroxime	10x125 mgc	2x500 mg, 10-14 days	8 (10 days)	0	n/a
		2x500 mg, 14 days	12	8
		2x500 mg, 28 days	23	6
	10x250 mgc	2x500 mg, 10-14 days	4 (10 days)	0
		2x500 mg, 14 days	6	4
		2x500 mg, 28 days	12	8
	8x500 mg	2x500 mg, 10-14 days	3 (12 days)	0
		2x500 mg, 14 days	4	4
		2x500 mg, 28 days	7	0
	10x500 mgc	2x500 mg, 10-14 days	2 (10 days)	0
		2x500 mg, 14 days	3	2
		2x500 mg, 28 days	6	4
	12x500 mg	2x500 mg, 10-14 days	2 (12 days)	0
		2x500 mg, 14 days	3	8
		2x500 mg, 28 days	5	4
	14x500 mgc	2x500 mg, 10-14 days	2 (14 days)	0
		2x500 mg, 14 days	2	0
		2x500 mg, 28 days	4	0
	15x500 mg	2x500 mg, 10-14 days	2 (14 days)	2
		2x500 mg, 14 days	2	2
		2x500 mg, 28 days	4	4
	16x500 mgc	2x500 mg, 10-14 days	2 (14 days)	4
		2x500 mg, 14 days	2	4
		2x500 mg, 28 days	4	8
	20x500 mg	2x500 mg, 10-14 days	1 (10 days)	0
		2x500 mg, 14 days	2	12
		2x500 mg, 28 days	3	4
	24x500 mg	2x500 mg, 10-14 days	1 (12 days)	0
		2x500 mg, 14 days	2	20
		2x500 mg, 28 days	3	16
Norfloxacin	20x400 mgc	2x400 mg, 3 days	1	14	n/a

Co-amoxiclav – amoxicillin and clavulanic acid; n/a – not applicable; extra units of drugs are presented with reference to the original formulation

^aThe Intersectoral Society for Antibiotic Resistance Control (ISKRA) guidelines on antimicrobial treatment and prophylaxis of urinary tract infections

^bInternational Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases

^cincluded in Croatian national reimbursement lists on 1^st August 2018