Table 4.

Accordance of the package sizes of selected drugs with guidelines for urinary tract infections II

Drug	Package size	ISKRAa	Min No. of packages	Extra units	IDSAb	Min No. of packages	Extra units
Ciprofloxacin	10x250 mgc	2x500 mg, 7-10 days	4 (10 days)	0	2x500 mg, 7 days	3	2
		2x500 mg, 14 days	6	4
					1000 mg, 7 days (extended release)	n/a	n/a
		2x500 mg, 28 days	12	8
	10x500 mgc	2x500 mg, 7-10 days	2 (10 days)	0	2x500 mg, 7 days	2	6
		2x500 mg, 14 days	3	2
					1000 mg, 7 days (extended release)	n/a	n/a
		2x500 mg, 28 days	6	4
Fosfomycinum	1x2000 mgc	n/a			1x3000 mg	n/a	n/a
	2x2000 mg	n/a			1x3000 mg	n/a	n/a
	1x3000 mgc	n/a			1x3000 mg	1	0
	2x3000 mgc	n/a			1x3000 mg	1	1
Levofloxacin	1x500 mg	n/a			1x750 mg, 5 days	8	0.5
	5x500 mg	n/a			1x750 mg, 5 days	2	2.5
	7x500 mg	n/a			1x750 mg, 5 days	2	6.5
	10x500 mgc	n/a			1x750 mg, 5 days	1	2.5
	14x500 mg	n/a			1x750 mg, 5 days	1	6.5
Nitrofurantoin	30x50 mgc	2x100 mg, 7 days	1	2	2x100 mg, 5 days (monohydrate, macrocrystals)	1	10
Sulfametoxazole, trimethoprim	20x120 mgc	2x960 mg, 28 days	23	12	2x960 mg, 3 days	3	12
					2x960 mg, 14 days	12	16
	20x480 mgc	2x960 mg, 28 days	6	8	2x960 mg, 3 days	1	8
					2x960 mg, 14 days	3	4
	20x960 mgc	2x960 mg, 28 days	3	4	2x960 mg, 3 days	1	14
					2x960 mg, 14 days	2	12

n/a – not applicable; extra units of drugs are presented with reference to the original formulation

^aThe Intersectoral Society for Antibiotic Resistance Control (ISKRA) guidelines on antimicrobial treatment and prophylaxis of urinary tract infections

^bInternational Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases

^cincluded in Croatian national reimbursement lists on 1^st of August 2018