Table 1.

Characteristics of in silico patients at baseline

	Baseline
	Mean (SD)
PaCO2, mmHg	61 (5.2)
pH	7.24 (0.03)
SvO2, %	74 (9.3)
Shunt Fraction, %	34 (11.3)
CI, L min− 1 m− 2	5 (0.3)
MAP, mm Hg	90 (2.6)
PF ratio, mmHg	133 (75)
- Mild	244 (37)
- Moderate	152 (37)
- Severe	72 (9.6)
Cstat, ml cmH2O−1	22 (3.6)
VR, breaths min−1	12.5 (0.8)
VT, ml PBW	5.9 (0.08)

CI - Cardiac Index (indexed to body surface area), FiO₂ - Fraction of O₂ in inspired gas, PEEP - Positive End Expiratory Pressure, PF ratio – Ratio of Arterial oxygen tension to FiO₂, PaCO₂ - Arterial carbon dioxide tension, SvO₂ - Mixed Venous Oxygen Saturation, Cstat – Static Compliance, MAP – Mean Arterial pressure, VR – Respiratory Rate, ∆V – Tidal Volume

Baseline in silico patients at PEEP 5 cm H₂O, FiO₂ 1.0, plateau pressure 30 cmH₂O. PF ratio and Cstat recorded at PEEP 10 cmH₂O (as given in (15))