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. 2019 Feb 11;11:24. doi: 10.1186/s13148-019-0621-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Integration analysis results of DMGs based on different region CpGs and DEGs. a Barplot for different region DMGs. The y-axis is the number of DMGs. The x-axis labels different gene regions: TSS1500, TSS200, 5′UTR, 1stExon, body, and 3′UTR. TSS1500 refers to 200–1500 bases upstream of the transcriptional start site (TSS). TSS200 means 0–200 bases upstream of TSS. 5′UTR stands for the 5′ untranslated region located between the TSS and the ATG start site. 1stExon is short for the first exon of the gene. Body is the region between ATG start site and stop codon. 3′UTR is short for 3′ untranslated region that is between stop codon and poly-A tail. b Venn plot for different region DMGs. The numbers on the diagram represent the DMG numbers in a specific region or multiple regions. Each region name is labeled beside the region circle. c Barplot for the overlap genes between DEG and different region DMGs. The y-axis is the number of overlap genes. The x-axis labels different gene regions: TSS1500, TSS200, 5′UTR, 1stExon, body and 3′UTR. d Barplot of four groups that overlap in each region. Hyper-down represents hyper-methylated and downregulated genes. Hypo-up represents hypo-methylated and upregulated genes. Hyper-up represents hyper-methylated and upregulated genes. Hypo-down represents hypo-methylated and downregulated genes. The y-axis is the number of genes