Table 1.
List of top enriched GO terms and KEGG pathways of DEGs
| Direction | Terms | ID | Description | p value | p adjust |
|---|---|---|---|---|---|
| Upregulated | BP | GO:0036230 | Granulocyte activation | 2.18E−46 | 7.79E−43 |
| Upregulated | BP | GO:0002446 | Neutrophil mediated immunity | 4.19E−46 | 7.79E−43 |
| Upregulated | BP | GO:0042119 | Neutrophil activation | 4.90E−46 | 7.79E−43 |
| Upregulated | BP | GO:0002283 | Neutrophil activation involved in immune response | 1.10E−45 | 1.05E−42 |
| Upregulated | CC | GO:0030667 | Secretory granule membrane | 2.91E−23 | 1.57E−20 |
| Upregulated | CC | GO:0042581 | Specific granule | 2.18E−21 | 5.87E−19 |
| Upregulated | CC | GO:0070820 | Tertiary granule | 3.46E−19 | 6.21E−17 |
| Upregulated | CC | GO:0034774 | Secretory granule lumen | 2.28E−15 | 3.06E−13 |
| Upregulated | CC | GO:0060205 | Cytoplasmic vesicle lumen | 5.00E−15 | 5.09E−13 |
| Upregulated | MF | GO:0003779 | Actin binding | 1.70E−08 | 1.37E−05 |
| Upregulated | MF | GO:0031267 | Small GTPase binding | 1.58E−06 | 3.59E−04 |
| Upregulated | MF | GO:0019902 | Phosphatase binding | 1.59E−06 | 3.59E−04 |
| Upregulated | MF | GO:0051020 | GTPase binding | 1.78E−06 | 3.59E−04 |
| Upregulated | KEGG | hsa04380 | Osteoclast differentiation | 4.91E−12 | 1.32E−09 |
| Upregulated | KEGG | hsa04650 | Natural killer cell mediated cytotoxicity | 1.44E−11 | 1.94E−09 |
| Upregulated | KEGG | hsa04142 | Lysosome | 6.26E−09 | 5.61E−07 |
| Upregulated | KEGG | hsa04612 | Antigen processing and presentation | 8.95E−09 | 6.02E−07 |
| Upregulated | KEGG | hsa04145 | Phagosome | 3.97E−08 | 2.14E−06 |
| Downregulated | MF | GO:0005200 | Structural constituent of cytoskeleton | 1.42E−04 | 3.5E−02 |
BP biological process, MF molecular function, CC cell component, KEGG Kyoto Encyclopedia of Genes and Genomes