Table 3.
List of top enriched GO-BP terms for each region DMGs
| Direction | Region | ID | Description | p value | p adjust |
|---|---|---|---|---|---|
| Hyper-methylated | TSS1500 | GO:0031295 | T cell costimulation | 1.03E−09 | 1.40E−06 |
| Hyper-methylated | TSS1500 | GO:0031294 | Lymphocyte costimulation | 1.44E−09 | 1.40E−06 |
| Hyper-methylated | TSS1500 | GO:1903037 | Regulation of leukocyte cell-cell adhesion | 6.11E−08 | 3.95E−05 |
| Hyper-methylated | 5′UTR | GO:0050851 | Antigen receptor-mediated signaling pathway | 3.83E−08 | 9.36E−05 |
| Hyper-methylated | 5′UTR | GO:0050852 | T cell receptor signaling pathway | 3.88E−07 | 4.74E−04 |
| Hyper-methylated | 5′UTR | GO:0002768 | Immune response-regulating cell surface receptor signaling pathway | 9.75E−06 | 7.16E−03 |
| Hyper-methylated | 5′UTR | GO:0042110 | T cell activation | 1.17E−05 | 7.16E−03 |
| Hyper-methylated | 1stExon | GO:0050851 | Antigen receptor-mediated signaling pathway | 2.06E−07 | 3.81E−04 |
| Hyper-methylated | 1stExon | GO:0050852 | T cell receptor signaling pathway | 4.35E−06 | 2.86E−03 |
| Hyper-methylated | 1stExon | GO:0042110 | T cell activation | 4.64E−06 | 2.86E−03 |
| Hyper-methylated | Body | GO:0042110 | T cell activation | 6.82E−08 | 1.66E−04 |
| Hyper-methylated | Body | GO:0030217 | T cell differentiation | 3.62E−07 | 4.41E−04 |
| Hyper-methylated | Body | GO:0030098 | Lymphocyte differentiation | 5.90E−07 | 4.79E−04 |
| Hyper-methylated | 3′UTR | GO:0002791 | Regulation of peptide secretion | 5.12E−05 | 4.85E−02 |
| Hyper-methylated | 3′UTR | GO:0002700 | Regulation of production of molecular mediator of immune response | 6.12E−05 | 4.85E−02 |
| Hyper-methylated | 3′UTR | GO:0045429 | Positive regulation of nitric oxide biosynthetic process | 1.02E−04 | 4.85E−02 |
| Hypo-methylated | TSS1500 | GO:0002283 | Neutrophil activation involved in immune response | 2.28E−21 | 3.68E−18 |
| Hypo-methylated | TSS1500 | GO:0043312 | Neutrophil degranulation | 2.28E−21 | 3.68E−18 |
| Hypo-methylated | TSS1500 | GO:0002446 | Neutrophil mediated immunity | 2.44E−21 | 3.68E−18 |
| Hypo-methylated | TSS1500 | GO:0042119 | Neutrophil activation | 4.16E−21 | 4.70E−18 |
| Hypo-methylated | TSS1500 | GO:0036230 | Granulocyte activation | 7.50E−21 | 6.78E−18 |
| Hypo-methylated | TSS200 | GO:0002446 | Neutrophil mediated immunity | 5.50E−25 | 1.89E−21 |
| Hypo-methylated | TSS200 | GO:0036230 | Granulocyte activation | 2.75E−24 | 4.72E−21 |
| Hypo-methylated | TSS200 | GO:0002283 | Neutrophil activation involved in immune response | 6.79E−24 | 5.84E−21 |
| Hypo-methylated | 5′UTR | GO:0002446 | Neutrophil mediated immunity | 4.53E−19 | 1.10E−15 |
| Hypo-methylated | 5′UTR | GO:0002283 | Neutrophil activation involved in immune response | 8.81E−19 | 1.10E−15 |
| Hypo-methylated | 5′UTR | GO:0043312 | Neutrophil degranulation | 8.81E−19 | 1.10E−15 |
| Hypo-methylated | 5′UTR | GO:0042119 | Neutrophil activation | 1.33E−18 | 1.25E−15 |
| Hypo-methylated | 5′UTR | GO:0036230 | Granulocyte activation | 2.01E−18 | 1.51E−15 |
| Hypo-methylated | 1stExon | GO:0002446 | Neutrophil mediated immunity | 1.28E−20 | 3.48E−17 |
| Hypo-methylated | 1stExon | GO:0002283 | Neutrophil activation involved in immune response | 3.38E−20 | 3.48E−17 |
| Hypo-methylated | 1stExon | GO:0043312 | Neutrophil degranulation | 3.38E−20 | 3.48E−17 |
| Hypo-methylated | 1stExon | GO:0042119 | Neutrophil activation | 4.97E−20 | 3.84E−17 |
| Hypo-methylated | 1stExon | GO:0036230 | Granulocyte activation | 7.27E−20 | 4.50E−17 |
| Hypo-methylated | Body | GO:0042119 | Neutrophil activation | 7.07E−14 | 1.49E−10 |
| Hypo-methylated | Body | GO:0036230 | Granulocyte activation | 1.09E−13 | 1.49E−10 |
| Hypo-methylated | Body | GO:0002446 | Neutrophil mediated immunity | 1.41E−13 | 1.49E−10 |
TSS transcription start site, TSS1500 within 1500 bps of a TSS, TSS200 within 200 bps of a TSS, UTR untranslated region, 1stExon the first exon of a gene