Table 3.
Evaluation of functional associations between RA and SCFAs (butyric acid, acetic acid, and propionic acid). RA-associated genes from three disease genetics resources (OMIM, the GWAS Catalog, and ClinVar) were used separately and combined
Disease Genetics | Recall | Mean Ranking (top %) | Median Ranking (top %) | P-value |
---|---|---|---|---|
OMIM (15 RA genes) | 1.00 | 5.96 | 5.69 | 0.0023 |
GWAS (155 RA genes) | 1.00 | 5.69 | 5.69 | 0.0018 |
ClinVar (10 RA genes) | 1.00 | 5.69 | 5.69 | 0.0018 |
Combined (166 RA genes) | 1.00 | 5.69 | 5.69 | 0.0018 |