Table 1.
Patient characteristics
| Baseline characteristic | 3-weekly (n = 127) |
Weekly (n = 187) |
Total (n = 314) |
p-value |
|---|---|---|---|---|
| Centre | < 0,0011 | |||
| - USB | 124 (97,6%) | 0 (0%) | 124 (39,5%) | |
| - KSW | 3 (2,4%) | 58 (32%) | 61 (19,4%) | |
| - USZ | 0 (0%) | 129 (69%) | 129 (41,1%) | |
| Age at diagnosis, mean (SD) | 60.4 (8.1) | 59.9 (8.7) | 60.1 (8.5) | 0.5582 |
| Gender | 0.2731 | |||
| - Male | 102 (80.3%) | 139 (74.3%) | 241 (76.8%) | |
| - Female | 25 (19.7%) | 48 (25.7%) | 73 (23.2%) | |
| Tumor localisation | 0.1561 | |||
| - Oropharynx | 57 (45.2%) | 102 (54.8%) | 159 (51%) | |
| - Oral cavity | 30 (23.8%) | 27 (14.5%) | 57 (18.3%) | |
| - Hypopharynx | 21 (16.7%) | 27 (14.5%) | 48 (15.4%) | |
| - Larynx | 10 (7.9%) | 21 (11.3%) | 31 (9.9%) | |
| - CUP | 5 (4.0%) | 8 (4.3%) | 13 (4.2%) | |
| - Nasopharynx | 3 (2.4%) | 1 (0.5%) | 4 (1.3%) | |
| Smoking History | 0.0871 | |||
| - Smoker | 105 (92.9%) | 155(85.6%) | 260 (88.4%) | |
| - Non smoker | 8 (7.1%) | 26 (14.4%) | 34 (11.6%) | |
| HPV Status | 0.0931 | |||
| -Positive | 21 (16.5%) | 34 (18.2%) | 55 (17.5%) | |
| - Negative | 32 (25.2%) | 29 (15.5%) | 61 (19.4%) | |
| - Unknown | 74 (58.3%) | 124 (66.3%) | 198 (63.1%) | |
| T Stage | 0.0811 | |||
| - T0 | 0 | 1 (0.6%) | 1 (0.3%) | |
| - T1 | 14 (11.7%) | 29 (16.2%) | 43 (14.4%) | |
| - T2 | 36 (30.0%) | 74 (41.3%) | 110 (36.8%) | |
| - T3 | 31 (25.8%) | 35 (19.6%) | 66 (22.1%) | |
| - T4 | 39 (32.5%) | 40 (22.3%) | 79 (26.4%) | |
| N Stage | 0.6271 | |||
| - N0 | 24 (19.0%) | 43 (23.0%) | 67 (21.4%) | |
| - N1 | 13 (10.3%) | 25 (13.4%) | 38 (12.1%) | |
| - N2 | 83 (65.9%) | 112 (59.9%) | 195 (62.3%) | |
| - N3 | 6 (4.8%) | 7 (3.7%) | 13 (4.2%) | |
| M Stage | 0,4823 | |||
| - M0 | 115 (90.5%) | 160 (85.5%) | 275 (87.5%) | |
| - M1 | 5 (3.9%) | 3 (1.6%) | 8 (2.5%) | |
| Advanced Disease (> = T2 & > = N2) | 0,0341 | |||
| - Yes | 77 (64,2%) | 99 (51.1%) | 169 (56.3%) | |
| - No | 43 (35,8%) | 88 (48,9%) | 131 (43,7%) | |
| Type of CRT | 0.1471 | |||
| - Definitive | 78 (61.4%) | 126 (67.3%) | 204 (64.9%) | |
| - Adjuvant | 49 (38.6%) | 61 (32.7%) | 110 (35.1%) | |
SD Standard deviation, 1Chi-Square test; 2t-test; 3Fisher’s exact test