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. 2018 Dec 6;126(12):127003. doi: 10.1289/EHP3951

Figure 6.

Figure 6A and 6B are bar graphs plotting concentrations of fasting plasma insulin (nanograms per milliliter) of the wildtype and knockout female and male mice across arsenic (parts per billion) per folate (low and high) (x-axis) for the LFD and HFD, respectively. Figure 6C and 6D are bar graphs plotting HOMA I R values (y-axis) for the same.

Fasting plasma insulin and homeostasis model assessment–insulin resistance (HOMA-IR) values of male and female wild-type (WT) and As3mt-knockout (KO) mice fed a low (L) or high folate (H) diet and exposed to 0 or 100 ppb inorganic arsenic (iAs) in drinking water, before and after a high-fat diet (HFD), before and after switching from the low-fat diet (LFD) to the HFD: Fasting plasma insulin and HOMA-IR were measured after 24 weeks on a LFD (A,C) and after 8 weeks on a HFD (B, D). Mean±SE for n=13–20; specific N numbers are found in Table 1. p<0.05 using post hoc Student’s t-test for the following comparisons: S, males vs. females of the same diet, exposure, and genotype; F, low vs. high folate intake animals of the same genotype, exposure, and sex; G, WT vs. KO mice of the same sex, diet, and exposure; and E, 0 vs. 100 ppb iAs-exposed mice of the same sex, genotype, and folate level.