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. 2019 Feb 5;13:18. doi: 10.3389/fncel.2019.00018

Figure 3.

Figure 3

Effect of SMI on tyrosine hydroxylase (TH)-positive and Nissl positive neuron number in chronic MPTP/probenecid-lesioned mice. Panel (A) shows the representative slices of the control mice, model mice treated with vehicle, 10 mg/kg/day, and 26 mg/kg/day SMI successively. (×100, scale bar = 100 μm). Panel (B) shows the statistical results. Panel (C) shows the representative images of Nissl-stained neurons in the substantia nigra pars compacta (SNpc) of the control mice, model mice treated with vehicle, 10 mg/kg/d, and 26 mg/kg/day SMI successively (×100, scale bar = 100 μm). Panel (D) shows quantification of Nissl-stained neurons. Number of nigral TH-positive neuron and Nissl-stained neurons in each mouse was quantified at ×100 magnification and then normalized to its corresponding control. Data are expressed as mean ± SEM, n = 3. **P < 0.01 and ***P < 0.001, respectively as compared with untreated model group, respectively.