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. 2019 Feb 5;13:18. doi: 10.3389/fncel.2019.00018

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Copyright © 2019 He, Yang, Zhang, Hou, Xu, Hu, Xu, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of SMI on cyclic AMP responsive element binding (CREB) phosphorylation in chronic MPTP/probenecid-lesioned mice and CREB siRNA on mRNA expression of GDNF and BDNF in MPP⁺ treated SH-SY5Y cells. Panel (A) shows western blot bands of CREB and phosphorylation ofCREB (pCREB). Panel (B) shows relative expression of pCREB/CREB were quantified by densitometry analysis using Image J software on CREB and pCREB bands (n = 4). Data are expressed as mean ± SEM, *P < 0.05, **P < 0.01 and ***P < 0.001, respectively as compared with untreated model group, respectively. Panels (C,D) show relative expression of GDNF and BDNF mRNA by real time PCR. Data are expressed as mean ± SEM, ***P < 0.001.