Table 3.

Significantly enriched MetaCore process networks from $48\text{-hpf}$ slincR-MO zebrafish exposed to $1\text{ng}/\mathrm{mL}$ TCDD for 1 hour at the shield stage, in comparison with the vehicle control (0.1% DMSO).

Network name	FDR	Associated human gene
Immune response: Th17-derived cytokines	$2.946\times {10}^{-2}$	JUN, CXCL12, MMP9
Development: EMT Regulation of epithelial-to-mesenchymal transition	$2.946\times {10}^{-2}$	JUN, CDKN1B, TWIST1, CTGF, MMP9
Signal transduction: ESR1-nuclear pathway	$2.946\times {10}^{-2}$	CYP1A1, JUN, NFATC4, CXCL12, CYP1B1
Reproduction: FSH-beta signaling pathway	$2.946\times {10}^{-2}$	JUN, CDKN1B, FST, CTGF

Note: The Bioconductor package edgeR (statistical methodology based on the negative binomial distribution) was used to calculate the significant differentially expressed genes ($n=4$, BH-adjusted $p\le 0.05$), in comparison with the vehicle control (0.1% DMSO). The human orthologs of the gene list were then submitted to MetaCore to identify significantly enriched process networks using a hypergeometric distribution, where the p-value is the probability that a gene set maps to a manually curated GeneGo Process Network or is overrepresented in comparison with the background gene list. Enriched process networks were considered significant with an $\text{FDR}\le 0.05$. $\text{BH},\text{Benjamini-Hochberg}$; $\text{DMSO},\text{dimethyl}\text{sulfoxide}$; $\text{EMT},\text{epithelial}\text{to}\text{mesenchyme}\text{transition}$; $\text{FDR},\text{false}\text{discovery}\text{rate}\text{adjusted}p\text{-value}$; $\text{FSH-beta},\text{follicle-stimulating hormone beta subunit}$; $\text{hpf},\text{hours}\text{post}\text{fertilization}$; $\text{slincR-MO},slincR\text{morphant}$; $\text{TCDD},2,3,7,8\text{-tetrachlorodibenzo-}p\text{-dioxin}$.