Table 3.

Associations of time-weighted water arsenic and urinary arsenic with relative abundance of individual bacterial taxa.

Taxonomy	Mean (range) relative abundance, %	Standard deviation of relative abundance, %	βa (95% CI; relative abundance, %)	P-value	Adjusted P-valueb
Time-weighted water arsenic
Class RF3	0.02 (0–1.3)	0.09	0.01 (< 0.01, 0.02)	0.04	0.60
Order ML615J-28	0.02 (0–1.3)	0.09	0.01 (< 0.01, 0.02)	0.04	0.90
Time-weighted urinary arsenic
Class Epsilonproteobacteria	0.06 (0–1.7)	0.22	0.03 (< 0.01, 0.06)	0.04	0.49
Order Campylobacterales	0.06 (0–1.7)	0.22	0.03 (< 0.01, 0.06)	0.04	0.63
Genus Anaerostipes	0.03 (0–0.4)	0.04	0.01 (< 0.01, 0.01)	0.04	0.82
Genus Faecalibacterium	2.9 (0–13.6)	1.86	0.26 (0.03, 0.50)	0.03	0.82

^aCoefficient from linear regression model indicates difference in relative abundance of individual bacterial taxa in relation to per 1-SD increase in time-weighted water arsenic (75.7 μg/L) or urinary arsenic (193.8 μg/g creatinine), adjusting for sex, age, BMI, smoking, and education.

^bP values were corrected for multiple testing using the Benjamini-Hochberg procedure to control false discovery rate (FDR) ≤ 5%.