Table 1.

Structures and in Vitro Pharmacology Data for the Radioligands Selected for Screening and Evaluation with PET^a

				IC50 (nM)a
				COX-1		COX-2
radioligandb	R1	R2	clog D	monkey	human	monkey	human
[11C]PS1	O11CH3	MeO	3.72	4.6 ± 1.3	5.0 ± 5.2	>1000	>1000
[2H2,18F]PS2	OCD218F	MeO	3.84	3.6 ± 1.0	4.0 ± 2.0	>1000	840 ± 100
[11C]PS13	OCH2CF3	11CH3O	3.59	1.0 ± 0.3	1.0 ± 0.2	>1000	>1000

^aData are from ref 1.

^bIn Part 1 (ref 1), [¹¹C]PS1, [²H₂,¹⁸F]PS2, and [¹¹C]PS13 were denoted [¹¹C]5, [d₂-¹⁸F]6, and [¹¹C]20, respectively.