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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Drug Alcohol Depend. 2018 Jan 5;184:1–11. doi: 10.1016/j.drugalcdep.2017.10.031

Fig. 4. The effects of 30 mg/kg MTEP and CDPPB upon the behavior of adult mice in the marble-burying test. Marble burying, CDPPB, and high-dose MTEP in adult drinkers.

Fig. 4.

(A) There was a significant drinking X treatment interaction in the number of marbles buried. MTEP treatment decreased the number of marbles buried in both water and alcohol drinkers. There was also a trend toward more burying in vehicle-treated alcohol drinkers compared to water drinkers. (B) A significant treatment effect showed decreased burying in MTEP-treated animals compared to vehicle. There was also a trend toward more time spent burying in vehicle-treated alcohol drinkers compared to water drinkers. (C) There was a trend toward a treatment effect in latency to start burying, driven primarily by a significant increase in MTEP-treated alcohol drinkers compared to vehicle. Also, vehicle-treated alcohol drinkers had a shorter latency to start burying compared to water drinkers. The small sample size in MTEP-treated water drinkers was due to 4 animals that did not engage in any burying and therefore had no latency data. *p < 0.05 vs. vehicle treatment within same drinking group, +p < 0.05 vs. vehicle-treated water drinkers. Data represent mean + SEM of the number of animals indicated in parentheses.