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. Author manuscript; available in PMC: 2019 Feb 12.
Published in final edited form as: Am J Hematol. 2018 Oct 31;94(1):62–73. doi: 10.1002/ajh.25307

Figure 2.

Figure 2.

Frequencies of genes with variants considered as pathogenic or potentially pathogenic in (A) IR-exposed and (B) IR-unexposed PMF patients with known driver mutation (black) and in TN patients (white) as identified by whole exome sequencing of PBMC. (C) Pathways potentially affected in IR-exposed (black) and unexposed (white) PMF patients. (D) Copy-number alterations and copy-neutral loss of heterozygosity in 13 PMF patients previously exposed to ionizing radiation and in 17 unexposed PMF patients. IR: Ionizing Radiation; PMF: Primary Myelofibrosis; TN: patients negative for usual driver mutations in JAK2, MPL and CALR genes; Chr: chromosome; cnLOH: copy-nutral loss of heterozygosity; LOSS: copy-number loss; GAIN: copy-number gain.