Table 1.
Baseline characteristics of the study population, mean ± standard deviation/median-interquartile range or n (%)π
| Adequate response to dual therapy (n = 64) | Poor response to aspirin (n = 20) | Poor response to clopidogrel (n = 23) | Poor response to dual therapy (n = 16) | p | |
|---|---|---|---|---|---|
| Age, years β | 38.7 ± 4.0 | 39.7 ± 3.7 | 39.6 ± 4.1 | 40.5 ± 4.7 | 0.372 |
| Male, n (%) | 59 (92.2) | 18 (90.0) | 20 (87) | 16 (100.0) | 0.520 |
| BMI, kg/m2 | 29.9 ± 4.6 | 28.6 ± 3.1 | 29.8 ± 4.2 | 29.3 ± 4.0 | 0.668 |
| Hyperlipidemia, n (%) | 19 (29.7) | 9 (45) | 14 (60.9) | 10 (62.5) | 0.017 |
| Hypertension, n (%) | 23 (35.9) | 6 (30) | 6 (26.1) | 6 (37.5) | 0.810 |
| Diabetes mellitus, n (%) | 7 (10.9) | 3 (15) | 3 (13) | 1 (6.3) | 0.861 |
| Smoking, n (%) | 46 (71.9) | 13 (65.0) | 17 (73.9) | 11 (68.8) | 0.919 |
| Family history, n (%) | 4 (6.3) | 4 (20) | 6 (26.1) | 6 (37.5) | 0.008 |
| Total Chol. mg/dL β | 185.8 ± 48.7 | 188.4 ± 40.0 | 200.5 ± 48.7 | 208.7 ± 42.3 | 0.277 |
| HDL, mg/dLβ | 37.0 ± 11.8 | 36.4 ± 9.4 | 38.6 ± 7.9 | 34.3 ± 7.9 | 0.652 |
| LDL, mg/dLβ | 122.2 ± 34.1 | 126.0 ± 31.9 | 142.6 ± 42.1 | 137.3 ± 37.6 | 0.104 |
| Triglycerides, mg/dL¥ | 121.5(69.7-202.2) | 111.5(83.0-207.2) | 101.0(62.0-194.0) | 174.0(142.0-264.0) | 0.060 |
| Creatinine, mg/dL¥ | 0.80(0.80-0.90) | 0.80(0.70-0.90) | 0.80(0.80-1.00) | 0.90(0.80-0.97) | 0.417 |
| Hematocrit, %β | 43.0 ± 4.0 | 44.8 ± 4.8 | 42.3 ± 5.2 | 44.3 ± 2.6 | 0.202 |
| Platelet, 103 µL* β | 256.5 ± 45.5 | 309.4 ± 71.2 | 300.2 ± 81.1 | 300.3 ± 77.5 | 0.001 |
| LVEF, %¥ | 50.0(45.0-56.5) | 50.0(42.7-55.0) | 55.0(50.0-60.0) | 51.5(41.2-58.7) | 0.244 |
| Culprit artery, % | 0.449 | ||||
| LAD | 33 (51.6) | 11 (57.9) | 11 (47.8) | 9 (56.3) | |
| CX | 9 (14.1) | 6 (31.6) | 5 (21.7) | 3 (18.8) | |
| RCA | 22 (34.4) | 2 (10.5) | 7 (30.4) | 4 (25.0) | |
| Syntax Score | 17.6 ± 9.0 | 19.4 ± 10.7 | 17.6 ± 7.4 | 16.3 ± 7.3 | 0.766 |
| Aspirin aggregation time (AU x min) ‡β |
277.0 ± 98.9 | 789.1 ± 203.0 | 300.7 ± 133.7 | 738.0 ± 191.2 | < 0.001 |
| Clopidogrel aggregation time (AU x min) ¶¥ | 288.5 ± 234.0-376.0) | 347.0(280.2-407.2) | 608.0(523.0-728.0) | 685.0(607.2-766.0) | < 0.001 |
BMI: body-mass index; Chol: cholesterol; HDL: high-density lipoprotein; LDL: low-density lipoprotein; LVEF: left vetricular ejection fraction; LAD: left anterior descending artery; CX: circumflex artery; RCA: right coronary artery; AU: aggregation unit; min: minute.
p values < 0.05, dual therapy responders vs. other groups;
p value < 0.05, aspirin poor responders vs. adequate response to aspirin:
p values < 0.05, clopidogrel poor responders vs. adequate response to clopidogrel
Kruskal-Wallis test was used for multiple independent variables without normal distribution, and Mann-Whitney U test was used for binary comparisons;
π Categorical data were compared with a chi-square test. B One-way ANOVA test was used for multiple independent variables with normal distribution, and for post hoc analysis, Tamhane's T2 and Tukey test were used.