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. 2019 Feb 5;10:27. doi: 10.3389/fphar.2019.00027

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Copyright © 2019 Chowdhury, Ghosh, Das and Sil.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of STZ and ferulic acid on the markers of the diabetic pathophysiology. (A) Effect of ferulic acid on blood glucose level of STZ-triggered diabetic rats in both dose-dependent and time-dependent manner. CON: level of blood glucose on untreated rats; STZ: blood glucose level of STZ-induced rats; DIA + FA-1, DIA + FA-2, DIA + FA-3, DIA + FA-4: the level of blood glucose of ferulic acid-treated diabetic rats at a dose of 10, 30, 50, and 70 mg kg^-1 body wt. respectively for 8 weeks; (B) blood glucose level; (C) glycosylated Hb; (D) serum insulin level, (E) absolutebody weight of experimental rats, (F) absolute kidney weight, and (G) kidney-to-body weight ratio of experimental animals. CON: rats treated with vehicle only; FA-3: rats were subjected to only ferulic acid treatment at a dose of 50 mg kg^-1; STZ: diabetic control; STZ + FA-3: diabetic rats were subjected to ferulic acid treatment at a dose of 50 mg kg^-1. Values are represented as mean ± SEM (six animals in each experimental groups) for three independent experiments. “^∗” symbolizes values differing from CON (^∗P < 0.05) significantly; “#” denotes values differing from DIA (^#P < 0.05) significantly; no significant variance existed between untreated (CON) and ferulic acid treated (FA-3) groups.