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. 2019 Feb 5;10:27. doi: 10.3389/fphar.2019.00027

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Copyright © 2019 Chowdhury, Ghosh, Das and Sil.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of ferulic acid on STZ-mediated nephrotoxicity in type 1 diabetic rats. (A) Effect of ferulic acid on the level of BUN in serum alongside STZ mediated toxicity in the renal tissue of the experimental rats in a dose-dependent manner. CON: BUN level in rats treated with vehicle only; STZ: BUN level in STZ induced diabetic rats; STZ+FA-10, STZ+FA-30, STZ+FA-50, STZ+FA-70: BUN level in ferulic acid treated diabetic rats for 8 weeks at varied doses viz. 10, 30, 50, and 70 mg kg^-1 body wt. respectively; (B) serum creatinine level; (C) BUN level; (D) urinary albumin/urinary creatinine ratio; (E) level of uric acid; (F) SGOT level; (G) SGPT level; (H) Histological examination. H&E staining of sections of kidney tissues of rats; ×200 and histological score. CON: rats receiving vehicle only; FA-3: only ferulic acid treated rats (dose: 50 mg kg^-1 body wt.); STZ: receiving STZ (50 mg kg^-1 body wt.); STZ+ FA-3: post-diabetic induction, rats treated with ferulic acid (dose: 50 mg kg^-1 body wt.). Values are represented as mean ± SEM (six animals in each experimental groups) for three different experiments. “^∗” symbolizes values differing from CON (^∗P < 0.05) significantly; “#” denotes values differing from DIA (^#P < 0.05) significantly; no significant variance existed between untreated (CON) and ferulic acid treated (FA-3) groups.