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. 2019 Feb 5;10:73. doi: 10.3389/fphar.2019.00073

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Copyright © 2019 Bali, Bruszt, Tadepalli, Csurgyók, Nagy, Tompa and Hernádi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of different doses of memantine and PHA-543613 in monotreatments and in different combinations against scopolamine-induced (0.5 mg/kg, i.p.) amnesia. Text below the graph represents the injections given before testing a given treatment. Dose of memantine (s.c.) and PHA-543613 (s.c.) in the given experiment is shown after their abbreviation (Mem, PHA, respectively) in mg/kg. (A) In Experiment 1, a subeffective dose of memantine was combined with a subeffective dose of PHA-543613 (n = 9 Long Evans rats); (B,C) In Experiments 2 and 3, effective doses of memantine were combined with subeffective doses of PHA-543613 (n = 10 Long Evans rats and 8 Wistar rats, respectively); (D) In Experiment 4, a subeffective dose of PHA-543613 was tested with a dose of memantine that was higher than its most effective dose (n = 8 Wistar rats). Significance level of post hoc comparisons between a given treatment and scopolamine alone treatment were marked with asterisks above the bars: ^∗p < 0.05. Hash symbols mark the significance level of the difference between the alternation performance after the given treatment and the chance level (0.5, dashed line): (#) p < 0.1, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001.