Table 2. . Maternal adiposity related measures and newborn DNA methylation in effects of aspirin in gestation and reproduction (n = 391).
| BMI (per kg/m2) | CpG site | β | SE | p-value | Mean | Chr | Position | Gene | Relation to CpG island |
|---|---|---|---|---|---|---|---|---|---|
| cg02918970 | -0.00158 | 0.000294 | 7.73E-08 | 0.851 | 10 | 70621889 | STOX1 | ||
| cg03550075+ | 0.001377 | 0.0002632 | 1.66E-07 | 0.850 | 12 | 132278448 | SFRS8 | S Shore | |
| cg02236945+ | -0.000756 | 0.0001479 | 3.24E-07 | 0.876 | 2 | 191269737 | MFSD6 | N Shelf | |
| cg05072085‡+ | -0.000665 | 0.000133 | 5.77E-07 | 0.855 | 8 | 134198574 | WISP1 | ||
| cg13460858 | -0.000878 | 0.0001774 | 7.38E-07 | 0.148 | 9 | 96720652 | BARX1 | Island | |
| cg02975187+ | -0.002525 | 0.0005135 | 8.75E-07 | 0.855 | 22 | 18512423 | FLJ41941 | ||
| Obesity (BMI ≥30 kg/m2) | CpG site | β | SE | p-value | Mean | Chr | Position | Gene | Relation to CpG island |
| cg02975187 | -0.04081 | 0.007332 | 2.62E-08 | 0.855 | 22 | 18512423 | FLJ41941 | ||
| cg10739592 | 0.01975 | 0.003751 | 1.39E-07 | 0.815 | 8 | 129962331 | |||
| WC (per cm) | CpG site | β | SE | p-value | Mean | Chr | Position | Gene | Relation to CpG island |
| cg05072085‡+ | -0.000274 | 0.00005379 | 3.58E-07 | 0.855 | 8 | 134198574 | WISP1 | ||
| cg14420357‡ | -0.000332 | 0.0000667 | 6.44E-07 | 0.830 | 6 | 158464617 | SYNJ2 | ||
| WHR (per unit) | CpG site | β | SE | p-value | Mean | Chr | Position | Gene | Relation to CpG island |
| cg05905044 | -0.0879 | 0.01747 | 4.90E-07 | 0.745 | 17 | 10710010 | TMEM220-AS1 | ||
| cg12848697 | -0.06905 | 0.01373 | 4.94E-07 | 0.837 | 18 | 13133368 | N Shelf | ||
| Central obesity (WHR ≥ 0.85) | CpG site | β | SE | p-value | Mean | Chr | Position | Gene | Relation to CpG island |
| cg12053563 | -0.01162 | 0.001983 | 4.58E-09 | 0.835 | 14 | 29637580 | |||
| cg12549355 | -0.01113 | 0.00207 | 7.54E-08 | 0.732 | 21 | 11126993 | |||
| cg09073263 | -0.01584 | 0.003148 | 4.87E-07 | 0.754 | 20 | 61771440 | |||
| cg09324752 | -0.006796 | 0.001363 | 6.15E-07 | 0.812 | 22 | 39546207 | CBX7 | N_Shore | |
| cg06958525 | -0.008351 | 0.001676 | 6.26E-07 | 0.853 | 2 | 108370346 | GACAT1 | ||
| cg08807496 | -0.01196 | 0.002402 | 6.43E-07 | 0.794 | 2 | 241831618 | C2orf54 | S_Shelf | |
| cg07560064 | 0.006758 | 0.001366 | 7.46E-07 | 0.058 | 16 | 22018867 | C16orf52 | N_Shore | |
| cg19402503 | 0.01647 | 0.003343 | 8.33E-07 | 0.754 | 11 | 128211576 | |||
| cg15392364 | 0.01398 | 0.002848 | 9.16E-07 | 0.713 | 1 | 206976689 | IL19 | ||
| SST (per unit) | CpG site | β | SE | p-value | Mean | Chr | Position | Gene | Relation to CpG island |
| cg11416447 | 8.83E-05 | 0.00001631 | 6.19E-08 | 0.070 | 7 | 86781551 | DMTF1 | N Shore | |
| cg13536409+ | 0.0003112 | 0.00005912 | 1.41E-07 | 0.269 | 7 | 158498471 | NCAPG2 | S Shore | |
| cg02588321+ | 0.0002254 | 0.00004607 | 9.94E-07 | 0.192 | 7 | 22485037 | MGC87042 | ||
| Leptin (per ng/ml) | CpG site | β | SE | p-value | Mean | Chr | Position | Gene | Relation to CpG island |
| cg19625347 | -1.93E-07 | 3.69E-08 | 1.73E-07 | 0.888 | 3 | 133721889 | SLCO2A1 | ||
| cg01872122 | -2.25E-07 | 4.33E-08 | 2.15E-07 | 0.869 | 5 | 16940481 | MYO10 | S_Shelf | |
| cg07637375 | -2.73E-07 | 5.30E-08 | 2.73E-07 | 0.835 | 16 | 84210542 | DNAAF1 | ||
| cg10578324 | -4.20E-07 | 8.19E-08 | 2.82E-07 | 0.855 | 5 | 133187068 | |||
| cg03278488 | 2.22E-07 | 4.45E-08 | 5.83E-07 | 0.126 | 16 | 85044408 | ZDHHC7 | N_Shore | |
| cg14420357 | -2.54E-07 | 5.16E-08 | 8.82E-07 | 0.830 | 6 | 158464617 | SYNJ2 | ||
| cg05364570 | -2.08E-07 | 4.24E-08 | 8.92E-07 | 0.854 | 16 | 72984764 | ZFHX3 | ||
| cg01889485 | 3.94E-07 | 8.03E-08 | 9.15E-07 | 0.780 | 2 | 2233529 | MYT1L | ||
| cg06542302 | -2.62E-07 | 5.35E-08 | 9.41E-07 | 0.858 | 12 | 132924218 | S_Shore | ||
| cg16139161 | -4.15E-07 | 8.48E-08 | 9.78E-07 | 0.851 | 7 | 150069806 | REPIN1 | Island | |
Models adjusted for maternal age, income, infant sex and cell type distribution (estimated by cord blood reference).
Associations shown with p < 10-6. (In bold, Bonferroni genome significance at p < 6.01 × 10-8).
+ indicates significant for model 1 (adjusted for age and income).
‡same CpG site identified as for another adiposity measure (regardless of model 1 or 2).
BMI: Body mass index; SE: Standard error; SST: Sum of skinfolds; WC: Waist circumference; WHR: Waist-to-hip ratio.