Table 4.

Analyses of risk factors for depression among patients with cervical cancer

Predictive variables	Univariate analysis		Multivariate analysisa
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age ≥65 (≥65=1, <65=0)	1.35 (1.16–1.57)	<0.0001	1.12 (0.94–1.34)	0.204
Comorbidities
Diabetes mellitus	1.48 (1.24–1.77)	<0.0001	1.28 (1.05–1.55)	0.013
Hypertension	1.30 (1.12–1.50)	<0.0001	1.00 (0.83–1.19)	0.958
Congestive heart failure	1.95 (1.50–2.53)	<0.0001	1.55 (1.16–2.07)	0.003
COPD	1.16 (0.94–1.43)	0.178
Chronic kidney disease	1.36 (1.05–1.75)	0.019	1.11 (0.85–1.45)	0.447
Cirrhosis	1.66 (0.86–3.21)	0.130
Autoimmune disease	1.12 (0.81–1.54)	0.495
Cerebrovascular disease	1.65 (1.31–2.08)	<0.0001	1.34 (0.34–1.02)	0.022
Ischemic heart disease	1.41 (1.17–1.71)	<0.0001	1.07 (0.86–1.33)	0.554
Treatmentsb
Surgery alone	0.77 (0.67–0.90)	<0.001	0.87 (0.73–1.05)	0.143
Surgery with neoadjuvant and/or adjuvant chemoradiotherapy	1.16 (1.01–1.34)	0.043	1.12 (0.94–1.33)	0.206
Chemoradiotherapy without surgery	1.08 (0.92–1.26)	0.351

Notes:

^aAll factors with P<0.1 in the univariate analyses were included in the Cox multivariate analysis.

^bTreatment was analyzed as a time-dependent covariate in the Cox regression model.