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. 2019 Feb 8;11:1309–1319. doi: 10.2147/CMAR.S187001

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© 2019 Wang et al. This work is published and licensed by Dove Medical Press Limited

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PTPN9 negatively regulated the activation of Stat3 in colorectal cancer.

Notes: Overexpression of PTPN9 significantly inhibited the phosphorylation of Stat3 (A), while the phosphorylation of Stat3 was increased by knockdown of PTPN9 (B). (C) PTPN9 overexpression depressed the nuclear translocation of Stat3. (D) Expression of Stat3 in the cellular nucleus was significantly enhanced by knockdown of PTPN9. (E) PTPN9 mitigated the protein level of Bcl-xL. (F) Knockdown of PTPN9 facilitated Bcl-xL expression. An unpaired Student’s t-test (for comparisons of two groups) was used to evaluate statistical significance (*P<0.05).

Abbreviations: GFP, green fluorescent protein; PTPN9, protein tyrosine phosphatase nonreceptor type 9; sh, short hairpin; Stat3, signal transducer and activator of transcription 3.