Skip to main content
. Author manuscript; available in PMC: 2019 Apr 22.
Published in final edited form as: Nat Neurosci. 2018 Oct 22;21(11):1600–1608. doi: 10.1038/s41593-018-0247-5

Figure 1: Correlated spontaneous activity in awake ferret visual cortex reveals large-scale modular distributed functional networks.

Figure 1:

a. Timecourse of spontaneous activity measured with wide-field epifluorescence in an awake ferret (mean across pixels in ROI). b. Representative z-scored images of spontaneous events at times indicated in (a). c. Spontaneous activity correlation patterns (Pearson’s correlation) shown for 3 different seed points (green circle). Correlation patterns span millimeters, can show both rapid changes between nearby seed points (left and middle) and long-range similarity for distant seed points (middle and right). d. Correlation patterns are highly similar in the awake and anesthetized cortex. e. Correlation values at maxima as a function of distance from the seed point showing that correlation amplitude remains strong over long distances. f-g. Spontaneous activity is modular and correlated at the cellular level (f) and shows good correspondence to spontaneous correlations obtained with wide-field imaging (g). h. Correlations measured under anesthesia are statistically similar to those in the awake cortex (n=5, grey: individual animals, black: mean ± SEM). Blue shaded region indicates within-state similarity (mean ± SEM). i. Cellular correlations are significantly similar to wide-field correlations (n=5, grey: individual animals, black: mean ± SEM). Blue region indicates within-modality similarity (mean ± SEM).