Figure 5: Spontaneous activity prior to eye-opening predicts future evoked responses.

a. Longitudinal imaging of a chronically-implanted animal reveals that early spontaneous correlation patterns exhibit signatures of the mature orientation map (right), despite considerable reorganization in correlation structure. Contour lines indicate horizontal selective domains measured at EO. b. The structure of spontaneous correlations can predict the future mature orientation preference map organization as early as 10 days before eye opening. c. Spontaneous correlation structure predicts orientation preference significantly better than chance, even at the youngest ages examined. For b, c: n=11 chronically recorded animals; c: asterisks indicate p<0.0001, actual vs surrogate data; c: group data is shown as mean ± SEM.