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. Author manuscript; available in PMC: 2019 Apr 22.
Published in final edited form as: Nat Neurosci. 2018 Oct 22;21(11):1600–1608. doi: 10.1038/s41593-018-0247-5

Figure 6: Long-range correlations in spontaneous activity persist in the absence of feed-forward input.

Figure 6:

a. Cortical spontaneous activity was measured before and following LGN inactivation via targeted muscimol infusion. b. Cortical responses (averaged across all pixels in ROI) to full-field luminance changes before (left) and after (right) LGN inactivation. Scale bars: 5 sec, 0.5 ΔF/F. c. Time-course of spontaneous activity for mean of all pixels before (top) and after (bottom) inactivation. Scale bars: 30 sec, 0.5 ΔF/F. d. Representative spontaneous events (left) and correlation patterns (Pearson’s correlation) (right) before (top) and after (bottom) inactivation. e. Similarity of correlation structure in representative experiment before and after inactivation for all cortical locations. f. Correlation structure was significantly more similar before and after inactivation than shuffled data (p<0.001 vs. shuffle, for 3 of 3 individual experiments, n=3 animals, bootstrap test). Error bars: mean ± SEM. g. The spatial scale of spontaneous correlations remains long-range following LGN inactivation (n=3 animals). Error bars: mean ± SEM. Scale bars: 1 mm (d,e).