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m dm2 knockout in p53-morphant zebrafish is not embryonic lethal if tp53 is temporarily repressed during embryogenesis. (A) mdm2−/− fish grow to adulthood, albeit physically smaller, and lack developed reproductive organs. (B) Immunohistochemical staining reveals that wild-type p53 does not accumulate in mdm2−/− adult fish while, in contrast, mutant p53 protein is stabilized in mdm2−/−p53M214K/M214K fish.
