| Collagen I |
High expression, disorganized, and high crosslinking |
Low expression, organized, and low crosslinking |
Col I maintains tissue structural integrity but excessive levels and high crosslinking are physical barriers to regeneration |
| Collagen III |
Decreased expression |
Increased expression |
Increased levels of col III offers a looser matrix network to allow cell migration, proliferation, and differentiation. Col III is required for col I fibrillogenesis. |
| HA |
Low levels |
High levels early and sustained |
Increased levels of HA in matrix facilitates cell movement, mitigates fibroblast proliferation, and augments inflammation |
| Tenacin C |
Late expression |
Early expression |
Early expression of tenascins enables cell migration for rapid epithelialization and wound closure |
| Fibronectin |
Later deposition |
Early deposition |
Early deposition of fibronectin provides cell anchorage points for rapid wound closure |
| MMP:TIMP ratio |
Low |
High |
High MMP:TIMP ratio favors matrix remodelling and turnover |
