Table 4.
Relationships Between Perinatal Methylation in Umbilical Cord at CpG Sites Within the RXRA Region of Interest and Bone Indices at Birth (Measured by DXA, Whole Body Minus Head)
| BA, (cm2) | BMC, (g) | aBMD, (g/cm2 ) | ||||
|---|---|---|---|---|---|---|
| RXRA CpG | β (95% CI) | p | β (95% CI) | p | β (95% CI) | p |
| CpG 5 | 4.18 (0.16, 8.20) | 0.04 | 1.50 (0.27, 2.74) | 0.02 | 0.002 (0.000, 0.004) | 0.05 |
| CpG 11 | 2.77 (−1.93, 7.48) | 0.25 | 0.84 (−0.61, 2.30) | 0.26 | 0.001 (−0.002, 0.004) | 0.47 |
| CpG 12 | 2.85 (−3.19, 8.88) | 0.35 | 0.62 (−1.25, 2.49) | 0.52 | 0.000 (−0.003, 0.003) | 0.91 |
Associations are adjusted for sex and treatment group. β coefficients and 95% CIs have been multiplied by 10 and therefore represent the change associated with a 10% increase in methylation. p values <0.05 are in bold.
BA = bone area; BMC = bone mineral content; aBMD = areal bone mineral density.