TABLE III.

HX-MS analysis of cluster II–specific mAbs LE4, CH1, SWB1, 6C4, and WECH1

		Strongly Protected Elementsa
mAb	Cluster	Peptides	Residues	Proximity
LE4	II	17–19	63–69	β-Strand d
		67, 68	154–161, 163	α-Helices D and E
CH1	II	67, 68, 70, 71	154–161, 163, 166, 167	α-Helices D and E
SWB1	II	67–69	154–161, 163	α-Helices D and E
6C4	II	19	64–68	β-Strand d
		83–88	184–187, 189–199, 210, 203, 205–206	α-Helices F and G
WECH1	II	2–4	14–20, 22–24	α-Helix A
		83–90	185–187, 189–199, 201, 203, 205–207	α-Helices F and G
.

^aActual exchange differences and entire RTA peptide list and corresponding residues are provided in Fig. 4 and Supplemental Table I