Table 2. Mean TTR, PINRR and % of patients poorly controlled considering NICE (TTR≥65%) and ESC (TTR≥70%) thresholds and different acceptable INR range definitions.
| Total | Women | Men | p-value | |
|---|---|---|---|---|
| Mean TTR and PINNR (Mean, SD) | ||||
| INR range 2–3 | ||||
| TTR | 63.0 (19.75) | 62.3 (19.71) | 63.7 (19.78) | <0.001 |
| PINRR | 59.2 (18.87) | 58.3 (18.81) | 60.1 (18.89) | <0.001 |
| INR 1.8–3.2 | ||||
| TTR | 76.2 (17.94) | 75.5 (17.96) | 76.8 (17.90) | <0.001 |
| PINRR | 72.8 (17.45) | 72.0 (17.51) | 73.6 (17.34) | <0.001 |
| % patients poorly controlled (INR range 2–3) | ||||
| TTR<65% | ||||
| TTR | 11,579 (51.2%) | 6,044 (53%) | 5,535 (49.3%) | <0.001 |
| PINRR | 14,058 (62.1%) | 7,338 (64.3%) | 6,720 (59.9%) | <0.001 |
| TTR< 70% | ||||
| TTR | 13,950 (61.7%) | 7,211 (63.2%) | 6,739 (60.1%) | <0.001 |
| PINRR | 15,950 (70.5%) | 8,252 (72.3%) | 7,698 (68.6%) | <0.001 |
| % patients poorly controlled (INR range 1.8–3.2) | ||||
| TTR< 65% | ||||
| TTR | 5,096 (22.5%) | 2,675 (23.4%) | 2,421 (21.6%) | 0.001 |
| PINRR | 6,928 (30.6%) | 3,716 (32.6%) | 3,212 (28.6%) | <0.001 |
| TTR< 70% | ||||
| TTR | 6,965 (30.8%) | 3,655 (32.0%) | 3,310 (29.5%) | <0.001 |
| PINRR | 8,951 (39.6%) | 4,736 (41.5%) | 4,215 (37.6%) | <0.001 |
TTR: Time in Therapeutic Range; PINNR: Percentage of INR determinations in Range; INR: International Normalized Ratio; INR: International Normalized Ratio.