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. 2019 Feb 12;14(2):e0211681. doi: 10.1371/journal.pone.0211681

Table 3. Factors associated with poor INR control.

Odds Ratio 95%CI p-value
Socio-demographics
Female 1.13 1.07; 1.20 <0.001
Age 65–75 (ref: age<65) 0.88 0.80; 0.97 0.010
Age 75 and over (ref: age<65) 0.87 0.80; 0.95 0.004
Europe (country) (ref: Spain) 1.23 1.05; 1.44 0.007
Income >18.000e (ref: income ≤18.000) 0.89 0.82; 0.96 0.002
Comorbidities
Congestive heart failure 1.19 1.12; 1.29 <0.001
Diabetes 1.14 1.08; 1.20 <0.001
Other bleeding 1.08 1.02; 1.14 0.011
Vascular disease 1.08 1.00; 1.16 0.036
Dementia 1.21 1.10; 1.35 <0.001
Depression 1.12 1.03; 1.20 0.005
Alcohol 1.70 1.25; 2.33 0.001
Healthcare utilisation
Time since Therapy Initiation >6 years 1.05 1.00; 1.11 0.047
ED visits 1.04 1.03; 1.06 <0.001
Outpatient visits 1.01 1.00; 1.01 <0.001
Specialist visits 1.02 1.01; 1.03 <0.001
Cardiology visits 0.96 0.93; 0.99 0.012
Neurologic visits 0.91 0.86; 0.95 <0.001
Social care visits 1.04 1.00; 1.09 0.017
Antiplatelet 1.11 1.00; 1.23 0.045

n = 22629; LL: -15461.213; p: <0.001; r2: 0.014; C Statistic: 0.579; p (X2 Hosmer-Lemeshow): 0.807.Age (<65, 65–75, >75) and Country (Spain, Europe, Non-Europe, Unknown) are categorical variables. Sex, income, comorbidity variables and Time since Therapy Initiation >6 years are dichotomous variables. Visits are quantitative variables (the variable is number of visits), and accordingly the Odds ratios refer to the odds of presenting a poor INR control with every additional visit.