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. 2019 Feb 12;14(2):e0212046. doi: 10.1371/journal.pone.0212046

Table 3. Joinpoint regression of the evolution of the age- and sex-standardised prevalence rate of polypharmacy (≥5 drugs) between 2000 and 2015.

Group SR in 2000–2015 (%) Summary AAPC Trend 1 Trend 2 Trend 3
Years APC (95%CI) Years APC (95%CI) Years APC (95%CI)
Total 18.0–25.2 2.0 (1.6; 2.4)**
Females 20.5–28.9 1.9 (1.4; 2.3)**
 <25 years 12.0–11.3 -0.3 (-0.9; 0.3)
 25–49 years 16.5–23.5 1.9 (1.4; 2.5)**
 50–74 years 294–41.8 1.8 (1.4; 2.3)**
 ≥75 years 28.4–51.0 3.5 (3.0; 4.0)** 2000–2009 4.6 (4.0; 5.2)** 2009–2013 0.3 (-2.7; 3.4) 2013–2015 8.3 (1.9; 15.2)**
Males 15.4–21.5 2.1 (1.7; 2.6)**
 <25 years 9.8–8.2 -1.3 (-2.0; -0.6)**
 25–49 years 10.2–13.7 1.6 (1.0; 2.1)**
 50–74 years 23.0–34.5 2.7 (2.2; 3.3)** 2000–2009 4.0 (3.2; 4.8)** 2009–2015 0.5 (-0.9; 1.9)
 ≥75 years 27.8–52.4 4.2 (3.7; 4.6)**

** p<0.05

SR: age- and sex-standardised prevalence rate; AAPC: Average annual percent change; APC: annual percent change; 95%CI: 95% confidence interval